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Preferential Interstrand Cross-Linking of DNA Rich in Guanine and Cytosine by cis-Dichlorodiammineplatinum(II)

โœ Scribed by Prasanta K. GANGULI; Theophile THEOPHANIDES


Book ID
115118551
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
661 KB
Volume
101
Category
Article
ISSN
1432-1327

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The combination of cis-diamminedichloroplatinum(ll) (CDDP) and 7-ethyl-I0-[4-( I -pipmidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To eluc