Sum ma ry DNA topoisomerases are enzymes that can modify, and may regulate, the topological state of DNA through concerted breaking and rejoining of the DNA strands. They have been believed to be directly involved in DNA excision repair, and perhaps to be required for the control of repair as well.
DNA Topoisomerase Protocols
β Scribed by J. Cummings
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 34 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1065-6995
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Type II DNA topoisomerase activity is required to change DNA topology. It is important in the relaxation of DNA supercoils generated by cellular processes, such as transcription and replication, and it is essential for the condensation of chromosomes and their segregation during mitosis. In mammals
Although the genetic code is defined by a linear array of nucleotides, it is the three-dimensional structure of the double helix that regulates most of its cellular functions. Over the past two decades, it has hecome increasingly clear that aspects of this three-dimensionality which reflect topologi