✦ LIBER ✦

DNA topoisomerases and DNA repair

✍ Scribed by C. S. Downes; R. T. Johnson

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 923 KB
Volume: 8
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950080602

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✦ Synopsis

Sum ma ry

DNA topoisomerases are enzymes that can modify, and may regulate, the topological state of DNA through concerted breaking and rejoining of the DNA strands. They have been believed to be directly involved in DNA excision repair, and perhaps to be required for the control of repair as well. The vicissitudes of this hypothesis provide a noteworthy example of the dangers of interpreting cellular phenomena without genetic informatior and vice versa. are with the Cancer Research Campaign Mammalian Cell DNA Repair Group,

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