Autoantigenic epitopes on dna topoisomerase i
β Scribed by Masataka Kuwana; Junichi Kaburaki; Tsuneyo Mimori; Takeshi Tojo; Mitsuo Homma
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 813 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective Previous studies have demonstrated that, once released into the extracellular environment, the systemic sclerosis (SSc)βassociated autoantigen DNA topoisomerase I (topo I) binds specifically to the surface of fibroblasts via an unknown receptor. We extended these results b
## Objective: To characterize an immunodominant epitope recognized by anti-dna topoisomerase i (topo i) antibody, a major autoantibody in sera of patients with systemic sclerosis (ssc). ## Methods: Topo i fragments were generated as fusion proteins using a bacterial expression system as well as p
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