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DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

✍ Scribed by Masaki Okano; Daphne W Bell; Daniel A Haber; En Li


Book ID
117268410
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
415 KB
Volume
99
Category
Article
ISSN
0092-8674

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Dynamic expression of de novo DNA methyl
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## Abstract To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is det