Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
โ Scribed by Kaneda, Masahiro; Okano, Masaki; Hata, Kenichiro; Sado, Takashi; Tsujimoto, Naomi; Li, En; Sasaki, Hiroyuki
- Book ID
- 109892988
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 322 KB
- Volume
- 429
- Category
- Article
- ISSN
- 0028-0836
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## Abstract To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is det
## Abstract Transcriptional silencing during differentiation of human male germ cells and serum starvation of human fibroblasts is controlled by epigenetic mechanisms that involve de novo DNA methylation. It is associated with high expression of different trancripts of the DNA methyltransferase 3A