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De Novo Methylation of Nucleosomal DNA by the Mammalian Dnmt1 and Dnmt3A DNA Methyltransferases †

✍ Scribed by Gowher, Humaira; Stockdale, Chris J.; Goyal, Rachna; Ferreira, Helder; Owen-Hughes, Tom; Jeltsch, Albert

Book ID
119940672
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
238 KB
Volume
44
Category
Article
ISSN
0006-2960

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✍ Jian Feng; Hua Chang; En Li; Guoping Fan 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 889 KB

## Abstract To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is det