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De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2′-deoxycytidine

✍ Scribed by Oka, Masahiro; Meacham, Amy M; Hamazaki, Takashi; Rodić, Nemanja; Chang, Lung-Ji; Terada, Naohiro


Book ID
110069595
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
425 KB
Volume
24
Category
Article
ISSN
0950-9232

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Dynamic expression of de novo DNA methyl
✍ Jian Feng; Hua Chang; En Li; Guoping Fan 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 889 KB

## Abstract To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is det