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Divergence in regulation of the PEA3 family of ETS transcription factors

✍ Scribed by Myriam Roussigné; Patrick Blader

Book ID: 113802378
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 278 KB
Volume: 6
Category: Article
ISSN: 1567-133X
DOI: 10.1016/j.modgep.2006.01.008

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The PEA3 group of transcription factors belongs to the ets family and is composed of 3 known members, PEA3, ERM and ER81, which are more than 95% identical within the DNAbinding ETS domain and exhibit 50% aa identity overall. Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been show