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Function of PEA3 Ets Transcription Factors in Mammary Gland Development and Oncogenesis

✍ Scribed by Natasza A. Kurpios; Nancy A. Sabolic; Trevor G. Shepherd; Gina M. Fidalgo; John A. Hassell

Book ID
111554765
Publisher
Springer US
Year
2003
Tongue
English
Weight
163 KB
Volume
8
Category
Article
ISSN
1083-3021

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The PEA3 group of transcription factors belongs to the ets family and is composed of 3 known members, PEA3, ERM and ER81, which are more than 95% identical within the DNAbinding ETS domain and exhibit 50% aa identity overall. Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been show