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Structure–Function Relationships of the PEA3 Group of Ets-Related Transcription Factors

✍ Scribed by Yvan de Launoit; Jean-Luc Baert; Anne Chotteau; Didier Monte; Pierre-Antoine Defossez; Laurent Coutte; Hélène Pelczar; Frauke Leenders

Book ID
112238222
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
429 KB
Volume
61
Category
Article
ISSN
1077-3150

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The PEA3 group of transcription factors belongs to the ets family and is composed of 3 known members, PEA3, ERM and ER81, which are more than 95% identical within the DNAbinding ETS domain and exhibit 50% aa identity overall. Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been show