Distinct chromosome abnormalities in ataxia telangiectasia with chronic T-cell lymphocytic leukemia
✍ Scribed by Reinhard Becher; Carsten Dührsen
- Book ID
- 119103435
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 469 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0165-4608
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Ataxia telangiectasia (A-T) is an autosomal recessive disorder in which patients show an unusual predisposition to malignant disease, including T-cell chronic lymphocytic leukaemia. We report here the steady growth over 5 years of a complex, cytogenetically abnormal clone of T lymphocytes in an A-T
We performed a cytogenetic study on 16 murine mature B-cell lymphomas and 10 T-cell lymphomas, using G-banding techniques. All tumors, with the exception of 3 spontaneous 6-cell tumors, were induced by various slowly transforming murine leukemia viruses (MuLV). Metaphases were obtained from primary