Distinct chromosomal abnormalities in murine leukemia virus-induced T- and B-cell lymphomas

✍ Scribed by W. L. E. Vasmel; E. A. Matthews; C. P. M. Gillis; J. Nieland; E. A. Borst; C. J. M. Leupers; C. J. M. Melief; R. M. Slater

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: French
• Weight: 980 KB
• Volume: 43
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910430626

✦ Synopsis

We performed a cytogenetic study on 16 murine mature B-cell lymphomas and 10 T-cell lymphomas, using G-banding techniques. All tumors, with the exception of 3 spontaneous 6-cell tumors, were induced by various slowly transforming murine leukemia viruses (MuLV). Metaphases were obtained from primary (10 6-cell tumors) and first or second transplant generation lymphomas (6 6-cell and 10 T-cell tumors), all of which were well characterized with respect to phenotypic, histologic and genotypic features. In the T-cell tumors we found relatively simple karyotypic abnormalities, including various numerical aberrations, such as trisomy 15, in line with many earlier reports. However, the majority of 6-cell tumors showed a great variety of both structural and numerical chromosomal anomalies. Three 6-cell lymphomas had an apparently normal karyotype. No single cytogenetic abnormality occurred commonly in the 6-cell lymphomas, but some structural abnormalities were found in more than one stemline, in particular, ins (I I) (Al; A2) in 3 tumors, and deletions involving the D-region of chromosome 14 in 3 other lymphomas. These cytogenetic results clearly indicate that the pathogenic mechanisms involved in MuLV-induced (long latency) 6-cell lymphomagenesis and (short latency) T-cell lymphomagenesis differ considerably. ~ 3 T ~ whom reprint requests should be addressed.