Abnormalities in T-cell associated rearrangement of T-cell receptor gamma chain genes in B-cell chronic lymphocytic leukemia
β Scribed by Brian F. Leber; John J. Murphy; John D. Norton
- Book ID
- 113239057
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 611 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0145-2126
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## Abstract We studied rearrangement of human T cell receptor genes (TCR) of CΞ², CΞ³, VΞ³ and JΞ³ in 34 cases of adult T cell leukemia/lymphoma (ATLL), consisting of 29 cases with monoclonally integrated HTLVβI proviral DNA (ATLLβW) and five without monoclonal integration (ATLLβO), in comparison with
B chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease. The different morphological variants of leukemic B cells appear to define different clinical groups of patients. Several abnormalities have been found in T lymphocytes and natural killer (NK) cells from B-CLL patients. We have invest