Dissociation mechanisms for metal N-glycosides of N-acetyl neuraminic acid
โ Scribed by Michael D. Leavell; Julie A. Leary
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 362 KB
- Volume
- 204
- Category
- Article
- ISSN
- 1387-3806
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๐ SIMILAR VOLUMES
N-Acetylneuraminic acid (1) can be transformed into the methyl a-u-ketoside 2 which, by reaction with methanesulfonyl chloride, yields the corresponding 4-0 mesylate 3 and the 4.7-di-0 -mesylate 4 as a by-product. Compound 3 reacts with Nal giving the 4-dcoxy-4-iodo compound 5 with cquatorial orient
Integration between the alkaline epimerization of N-acetyl-D-glucosamine (GlcNAc) to N-Acetyl-Dmannosamine (ManNAc) and the N-acetyl-D-neuraminic acid (Neu5Ac) aldolase-catalyzed biotransformation has been assessed experimentally. GlcNAc epimerization took place above pH 9.0, and the initial rate of