Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity †
✍ Scribed by Pratt, David J.; Bentley, Jo; Jewsbury, Philip; Boyle, F. Tom; Endicott, Jane A.; Noble, Martin E. M.
- Book ID
- 120416049
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 452 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2623
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Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation. p16 an
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