Cyclin D-dependent kinases, INK4 inhibitors and cancer
β Scribed by Sagrario Ortega; Marcos Malumbres; Mariano Barbacid
- Book ID
- 114222820
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 437 KB
- Volume
- 1602
- Category
- Article
- ISSN
- 0304-419X
No coin nor oath required. For personal study only.
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Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation. p16 an
## Abstract Cyclin dependent kinases (Cdks) are essential enzymes for the control of cell cycle progression. Inhibitors of cyclinβdependent kinases are anticipated to possess therapeutic utility against a wide variety of proliferative diseases, especially cancer. The field of published small molecu