ChemInform Abstract: Identification of Selective Inhibitors of Cyclin Dependent Kinase 4.
β Scribed by David J. Carini; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable via the βReferencesβ option.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract CDK2 inhibitors containing the related bicyclic heterocycles pyrazolopyrimidines and imidazopyrazines were discovered through highβthroughput screening. Crystal structures of inhibitors with these bicyclic cores and two more related ones show that all but one have a common binding mode