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2-Aminoquinazoline Inhibitors of Cyclin-Dependent Kinases.

✍ Scribed by Yadagiri Bathini; Inderjit Singh; Patricia J. Harvey; Paul R. Keller; Rajeshwar Singh; Ronald G. Micetich; David W. Fry; Ellen M. Dobrusin; Peter L. Toogood


Publisher
John Wiley and Sons
Year
2005
Weight
13 KB
Volume
36
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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## Abstract CDK2 inhibitors containing the related bicyclic heterocycles pyrazolopyrimidines and imidazopyrazines were discovered through high‐throughput screening. Crystal structures of inhibitors with these bicyclic cores and two more related ones show that all but one have a common binding mode