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Disrupted adult neurogenesis in a novel rat model of Alzheimer's disease

✍ Scribed by Rezai-Zadeh, Kavon; Breunig, Joshua; Rentsendorj, Altan; Gate, David; Cohen, Robert; Town, Terrence

Book ID
123122816
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
108 KB
Volume
7
Category
Article
ISSN
1552-5260

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Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-␀ 42 (A␀ 42 )-containing plaques