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P3-384: Impaired hippocampal adult neurogenesis in an animal model of Alzheimer's disease

✍ Scribed by Halabisky, Brian E.; Sun, Binggui; Zhou, Yungui; Mueller-Steiner, Sarah; Wang, Xin; Yu, Giuqiu; Mucke, Lennart; Gan, Li

Book ID
122578220
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
51 KB
Volume
4
Category
Article
ISSN
1552-5260

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Decreased adult hippocampal neurogenesis
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Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-␀ 42 (A␀ 42 )-containing plaques