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Adult Neurogenesis Is Altered by GABAergic Imbalance in Models of Alzheimer's Disease

✍ Scribed by Alejandro F. Schinder; Nicolás A. Morgenstern


Book ID
116891272
Publisher
Elsevier
Year
2009
Tongue
English
Weight
60 KB
Volume
5
Category
Article
ISSN
1934-5909

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✍ Michael H. Donovan; Umar Yazdani; Rebekah D. Norris; Dora Games; Dwight C. Germa 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-␤ 42 (A␤ 42 )-containing plaques