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Adult neurogenesis is diminished in a novel rat model of Alzheimer's disease

✍ Scribed by Breunig, Joshua; Rezai-Zadeh, Kavon; Rentsendorj, Altan; Gate, David; Cohen, Robert; Town, Terrence

Book ID
123161319
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
84 KB
Volume
8
Category
Article
ISSN
1552-5260

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Decreased adult hippocampal neurogenesis
Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
✍ Michael H. Donovan; Umar Yazdani; Rebekah D. Norris; Dora Games; Dwight C. Germa πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 623 KB

Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-␀ 42 (A␀ 42 )-containing plaques