Discriminative stimulus control with olanzapine: generalization to the atypical antipsychotic clozapine
โ Scribed by J. H. Porter; Sarah E. Strong
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 317 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0033-3158
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๐ SIMILAR VOLUMES
The discriminative stimulus properties of the typical antipsychotic chlorpromazine were examined in a two-lever drug discrimination procedure for food reward. Six of nine rats readily acquired the discrimination between 1.0 mg/kg chlorpromazine (i.p.) and vehicle in a mean of 29.7 training sessions.
The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do