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Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats

โœ Scribed by Joseph H. Porter; Adam J. Prus; Robert E. Vann; Stephen A. Varvel


Publisher
Springer
Year
2004
Tongue
English
Weight
290 KB
Volume
178
Category
Article
ISSN
0033-3158

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The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do