The discriminative stimulus properties of the typical antipsychotic chlorpromazine were examined in a two-lever drug discrimination procedure for food reward. Six of nine rats readily acquired the discrimination between 1.0 mg/kg chlorpromazine (i.p.) and vehicle in a mean of 29.7 training sessions.
โฆ LIBER โฆ
Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats
โ Scribed by Joseph H. Porter; Adam J. Prus; Robert E. Vann; Stephen A. Varvel
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 290 KB
- Volume
- 178
- Category
- Article
- ISSN
- 0033-3158
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The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do