Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors

✍ Scribed by Olson, David E.; Wagner, Florence F.; Kaya, Taner; Gale, Jennifer P.; Aidoud, Nadia; Davoine, Emeline L.; Lazzaro, Fanny; Weïwer, Michel; Zhang, Yan-Ling; Holson, Edward B.

• Book ID: 120332934
• Publisher: American Chemical Society
• Year: 2013
• Tongue: English
• Weight: 995 KB
• Volume: 56
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm400390r

✦ Synopsis

We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8.