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ChemInform Abstract: Discovery of Histone Deacetylase 8 Selective Inhibitors.

✍ Scribed by Weiping Tang; Tuoping Luo; Edward F. Greenberg; James E. Bradner; Stuart L. Schreiber

Publisher
John Wiley and Sons
Year
2012
Weight
30 KB
Volume
43
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

A library of small molecule inhibitors of histone deacetylase is prepared by coupling of macrocyclic aldehydes such as (VII) with bifunctional hydrazide reagents.

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