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Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors

✍ Scribed by Arturo J. Vegas; James E. Bradner; Weiping Tang; Olivia M. McPherson; Edward F. Greenberg; Angela N. Koehler; Stuart L. Schreiber

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
784 KB
Volume
119
Category
Article
ISSN
0044-8249

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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we