𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors

✍ Scribed by Olson, David E.; Wagner, Florence F.; Kaya, Taner; Gale, Jennifer P.; Aidoud, Nadia; Davoine, Emeline L.; Lazzaro, Fanny; Weïwer, Michel; Zhang, Yan-Ling; Holson, Edward B.


Book ID
120332933
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
995 KB
Volume
56
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Discovery of the First Histone Deacetyla
✍ Olson, David E.; Wagner, Florence F.; Kaya, Taner; Gale, Jennifer P.; Aidoud, Na 📂 Article 📅 2013 🏛 American Chemical Society 🌐 English ⚖ 995 KB

We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta s

ChemInform Abstract: Discovery of Histon
✍ Weiping Tang; Tuoping Luo; Edward F. Greenberg; James E. Bradner; Stuart L. Schr 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

## Abstract A library of small molecule inhibitors of histone deacetylase is prepared by coupling of macrocyclic aldehydes such as (VII) with bifunctional hydrazide reagents.