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Discovery of ( S )- N -{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1 H -isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

✍ Scribed by Man, Hon-Wah; Schafer, Peter; Wong, Lu Min; Patterson, Rebecca T.; Corral, Laura G.; Raymon, Heather; Blease, Kate; Leisten, Jim; Shirley, Michael A.; Tang, Yang; Babusis, Darius M.; Chen, Roger; Stirling, Dave; Muller, George W.

Book ID: 120382859
Publisher: American Chemical Society
Year: 2009
Tongue: English
Weight: 73 KB
Volume: 52
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm900210d

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