✦ LIBER ✦

Discovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A1 Receptor Antagonist with Potent Diuretic Activity

✍ Scribed by Akahane, Atsushi; Katayama, Hirohito; Mitsunaga, Takafumi; Kato, Takeshi; Kinoshita, Takayoshi; Kita, Yasuhiro; Kusunoki, Takahiro; Terai, Takao; Yoshida, Keizo; Shiokawa, Youichi

Book ID: 111685143
Publisher: American Chemical Society
Year: 1999
Tongue: English
Weight: 75 KB
Volume: 42
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm980671w

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Novel adenosine A1 receptor antagonists.

Novel adenosine A1 receptor antagonists. Synthesis and structure–activity relationships of a novel series of 3-(2-cyclohexenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridines

✍ Satoru Kuroda; Atsushi Akahane; Hiromichi Itani; Shintaro Nishimura; Kieran Durk 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 251 KB

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

✍ Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 835 KB

Pharmacological Characterization of MK-0

Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

✍ Salvatore, C. A.; Hershey, J. C.; Corcoran, H. A.; Fay, J. F.; Johnston, V. K.; 📂 Article 📅 2007 🏛 American Society for Pharmacology and Experimental 🌐 English ⚖ 370 KB

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-Tetrazol-5-

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist

✍ Ornstein, Paul L.; Arnold, M. Brian; Augenstein, Nancy K.; Lodge, David; Leander 📂 Article 📅 1993 🏛 American Chemical Society 🌐 English ⚖ 369 KB

In Vitro and in Vivo Characterization of

In Vitro and in Vivo Characterization of 3-{2-[6-(2- tert -Butoxyethoxy)pyridin-3-yl]-1 H -imidazol-4-yl}benzonitrile Hydrochloride Salt, a Potent and Selective NPY5 Receptor Antagonist

✍ Elliott, Richard L.; Oliver, Robert M.; Hammond, Marlys; Patterson, Terrell A.; 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 61 KB

Synthesis of [14C]KT3-671, 2-Propyl-8-ox

Synthesis of [14C]KT3-671, 2-Propyl-8-oxo-1-[ (2′-(1H-[14C] tetrazole-5-yl) biphenyl-4-yl) methyl]-4,5,6, 7-tetrahydro-cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist

✍ Naoto Ueyama; Takashi Yanagisawa; Tsuyoshi Tomiyama 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 263 KB 👁 1 views

## Abstract 2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in ^14^C‐labelled form by using potassium[^14^C]‐cyanide. [^14^C](KT3‐