✦ LIBER ✦

Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist

✍ Scribed by Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine, Yoshihiko; Takenaka, Osamu; Hanada, Takahisa; Yonaga, Masahiro

Book ID: 118064535
Publisher: American Chemical Society
Year: 2012
Tongue: English
Weight: 835 KB
Volume: 55
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm301268u

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and 5-HT2A, 5-HT1A and α1-Bind

Synthesis and 5-HT2A, 5-HT1A and α1-Binding Affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes

✍ Elisabetta Orlandini; Simona Rapposelli; Susanna Nencetti; Gino Giannaccini; Lau 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 288 KB 👁 1 views

Synthesis of 2-methoxy-2-methyl-3-{6-[2-

Synthesis of 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoic acid, a dual PPARα/γ agonist

✍ Paul S. Humphries; Quyen-Quyen T. Do; David M. Wilhite 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 291 KB

Large quantities of an enantiomerically pure novel dual PPARa/c agonist were required. Three routes were successfully developed to achieve this goal, with the chosen route utilized to deliver 40 g of material.

Resolution, configurational assignment,

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist

✍ Stine B. Vogensen; Henrik S. Jensen; Tine B. Stensbøl; Karla Frydenvang; Benny B 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com

Discovery of a Potent, Selective, and Or

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)- N -(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazole-4-carboxamide (AMG 458)

✍ Liu, Longbin; Siegmund, Aaron; Xi, Ning; Kaplan-Lefko, Paula; Rex, Karen; Chen, 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 191 KB

Synthesis of N-(2,3-dihydro-1-[14C]methy

Synthesis of N-(2,3-dihydro-1-[14C]methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-benzamide and N-(2,3-dihydro-1-[14C]methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N-[14C]methyl-benzamide as novel carbon-14 labelled CCK antagonists

✍ Hojatollah Matloubi; Ali Khalaj; Reza Dowlatabadi; Gholamhossein Shirvani 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 74 KB 👁 1 views

## Abstract Two benzodiazepine CCK antagonists __N__‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H 1,4‐benzodiazepin‐3‐yl)‐benzamide **2** and __N__‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐[^14^C]methyl‐benzamide **3** were synthesized in high yields through the reac

ChemInform Abstract: Discovery of a Fact

ChemInform Abstract: Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic Acid 3-[(5-Chloro-pyridin-2-yl)-amide] 4-{[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a Clinical Candidate.

✍ Wolfgang Haap; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

## Abstract Compound (I) is found to be a potent, selective and orally bioavailable fXa inhibitor based on a pyrrolidine scaffold.