✦ LIBER ✦

Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1 H -indazol-5-ylamino]-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yl]carbamic Acid, (3 S )-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases

✍ Scribed by Gavai, Ashvinikumar V.; Fink, Brian E.; Fairfax, David J.; Martin, Gregory S.; Rossiter, Lana M.; Holst, Christian L.; Kim, Soong-Hoon; Leavitt, Kenneth J.; Mastalerz, Harold; Han, Wen-Ching; Norris, Derek; Goyal, Bindu; Swaminathan, Shankar; Patel, Bharat; Mathur, Arvind; Vyas, Dolatrai M.; Tokarski, John S.; Yu, Chiang; Oppenheimer, Simone; Zhang, Hongjian; Marathe, Punit; Fargnoli, Joseph; Lee, Francis Y.; Wong, Tai W.; Vite, Gregory D.

Book ID: 118138013
Publisher: American Chemical Society
Year: 2009
Tongue: English
Weight: 912 KB
Volume: 52
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9010065

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of Brivanib Alaninate (( S )-(

Discovery of Brivanib Alaninate (( S )-(( R )-1-(4-(4-Fluoro-2-methyl-1 H -indol-5-yloxy)-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215)

✍ Cai, Zhen-wei; Zhang, Yongzheng; Borzilleri, Robert M.; Qian, Ligang; Barbosa, S 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 243 KB

ChemInform Abstract: Discovery and Precl

ChemInform Abstract: Discovery and Preclinical Studies of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo [2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo Active Potent VEGFR-2 Inhibitor.

✍ Rejean Ruel; et al. et al. 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 20 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Discovery and Evaluation of 4-(2-(4-chlo

Discovery and Evaluation of 4-(2-(4-chloro-1 H -pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1 H -benzo[ d ]imidazol-2-yl)pyridin-2(1 H )-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

✍ Velaparthi, Upender; Wittman, Mark; Liu, Peiying; Carboni, Joan M.; Lee, Francis 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 205 KB

Discovery of (1R,2R)-N-(4-(6-isopropylpy

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

✍ Hao, Junliang; Dehlinger, Veronique; Fivush, Adam M.; Rudyk, Helene C.E.; Britto 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 452 KB

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluor

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6- [2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl- [1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-on# e (I) (BMS-740808) a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.

✍ Donald J. P. Pinto; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 10 KB 👁 1 views

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1 H -pyrazolo[3,4- c ]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

✍ Pinto, Donald J. P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexan 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 666 KB