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Discovery and Evaluation of 4-(2-(4-chloro-1 H -pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1 H -benzo[ d ]imidazol-2-yl)pyridin-2(1 H )-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

✍ Scribed by Velaparthi, Upender; Wittman, Mark; Liu, Peiying; Carboni, Joan M.; Lee, Francis Y.; Attar, Ricardo; Balimane, Praveen; Clarke, Wendy; Sinz, Michael W.; Hurlburt, Warren; Patel, Karishma; Discenza, Lorell; Kim, Sean; Gottardis, Marco; Greer, Ann; Li, Aixin; Saulnier, Mark; Yang, Zheng; Zimmermann, Kurt; Trainor, George; Vyas, Dolatrai

Book ID: 120561385
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 205 KB
Volume: 51
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm800832q

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