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Direct resolution of enantiomers by impregnated TLC

✍ Scribed by R. Bhushan; J. Martens


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
80 KB
Volume
11
Category
Article
ISSN
0269-3879

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✦ Synopsis


Direct resolution of enantiomers has acquired greater analytical importance. Of various chromatographic techniques, TLC continues to enjoy considerable reputation for the purpose. The present paper deals with an important and yet less explored aspect of TLC i.e. impregnation. Methods of impregnation of thin layer material with a variety of reagents and the role of impregnating reagents in resolving compounds on these layers, with special reference to main/basic approaches of impregnation as applied to direct enantiomeric resolution, are discussed.


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Direct TLC resolution of atenolol and pr
✍ Ravi Bhushan; Shivani Tanwar πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 148 KB πŸ‘ 1 views

## Abstract Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure l‐tartaric acid, (__R__)‐mandelic acid and (–)‐erythromycin as chiral selectors. Different solvent systems were worked out t