Direct resolution of enantiomers by impregnated TLC
β Scribed by R. Bhushan; J. Martens
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 80 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0269-3879
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β¦ Synopsis
Direct resolution of enantiomers has acquired greater analytical importance. Of various chromatographic techniques, TLC continues to enjoy considerable reputation for the purpose. The present paper deals with an important and yet less explored aspect of TLC i.e. impregnation. Methods of impregnation of thin layer material with a variety of reagents and the role of impregnating reagents in resolving compounds on these layers, with special reference to main/basic approaches of impregnation as applied to direct enantiomeric resolution, are discussed.
π SIMILAR VOLUMES
## Abstract Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure lβtartaric acid, (__R__)βmandelic acid and (β)βerythromycin as chiral selectors. Different solvent systems were worked out t