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Direct enantiomeric resolution of (±)-atenolol, (±)-metoprolol, and (±)-propranolol by impregnated TLC using L-aspartic acid as chiral selector

✍ Scribed by R. Bhushan; Meenakshi Arora


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
140 KB
Volume
17
Category
Article
ISSN
0269-3879

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Direct TLC resolution of atenolol and pr
✍ Ravi Bhushan; Shivani Tanwar 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 1 views

## Abstract Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure l‐tartaric acid, (__R__)‐mandelic acid and (–)‐erythromycin as chiral selectors. Different solvent systems were worked out t