✦ LIBER ✦

Direct TLC resolution of atenolol and propranolol into their enantiomers using three different chiral selectors as impregnating reagents

✍ Scribed by Ravi Bhushan; Shivani Tanwar

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 148 KB
Volume: 22
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.1025

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure l‐tartaric acid, (R)‐mandelic acid and (–)‐erythromycin as chiral selectors. Different solvent systems were worked out to resolve the enantiomers. Spots were detected using iodine vapour. The TLC method was validated for linearity, limit of detection and limit of quantification. The influence of pH, temperature and concentration of chiral selector was studied. Copyright © 2008 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Direct enantiomeric resolution of (±)-at

Direct enantiomeric resolution of (±)-atenolol, (±)-metoprolol, and (±)-propranolol by impregnated TLC using L-aspartic acid as chiral selector

✍ R. Bhushan; Meenakshi Arora 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 2 views

Direct enantiomeric TLC resolution of dl

Direct enantiomeric TLC resolution of dl-penicillamine using (R)-mandelic acid and l-tartaric acid as chiral impregnating reagents and as chiral mobile phase additive

✍ Ravi Bhushan; Charu Agarwal 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 112 KB 👁 1 views