𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Direct observation of a tetrahedral intermediate during amidine hydrolysis

✍ Scribed by Dwight R. Robinson

Book ID
104223046
Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
204 KB
Volume
9
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Recent experiments have led to the conclusion that the hydrolysis of the formamidinium compound, diphenylimidazolinium chloride (I, R = C6H5) proceeds through the rate determining decomposition of a tetrahedral intermediate (III) according to the mechanism of eq.1 (2).

πŸ“œ SIMILAR VOLUMES

Direct observation by X-ray analysis of
Direct observation by X-ray analysis of the tetrahedral β€œintermediate” of aspartic proteinases
✍ B. Veerapandian; Jon B. Cooper; Andrej Ε ali; Tom L. Blundell; Robert L. Rosati; πŸ“‚ Article πŸ“… 2008 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 652 KB

## Abstract We report the X‐ray analysis at 2.0 Γ… resolution for crystals of the aspartic proteinase endothiapepsin (EC 3.4.23.6) complexed with a potent difluorostatone‐containing tripeptide renin inhibitor (CP‐81,282). The scissile bond surrogate, an electrophilic ketone, is hydrated in the compl