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Direct measurement of heteronuclear long-range coupling constants from phase-sensitive HMBC spectra

✍ Scribed by Keyang Ding

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
54 KB
Volume
38
Category
Article
ISSN
0749-1581

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✦ Synopsis

A simple pulse sequence in inverse-detection mode is proposed for the detection of heteronuclear long-range couplings. In the resulting 2D heteronuclear multiple-bond correlation (HMBC) spectra, pure-absorptive peak patterns are obtained along both frequency dimensions. Since the heteronuclear couplings result in anti-phase splittings over the proton homonuclear multiplets along the ω 2 -dimension, the phase-sensitive HMBC experiment can be provided as an easy and direct means for the measurement of heteronuclear long-range coupling constants.

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