A Method for Measurement of Long-Range Heteronuclear Coupling Constants from 2D HMQC Spectra

✍ Scribed by Dušan Uhrı́n; Vikram Varma; Jean-Robert Brisson

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 123 KB
• Volume: 119
• Category: Article
• ISSN: 1064-1858
• DOI: 10.1006/jmra.1996.0060

✦ Synopsis

Long-range heteronuclear coupling constants, n J XH , have been recognized as an important source of information in the structural elucidation of molecules (1). Accordingly, a large number of methods for their measurement have been proposed to date . Often these methods rely on the characteristic spectral features of the class of compounds for which they were intended, e.g., separation of signals in proton or heteronuclear spectra (2,3,(12)(13)(14)(15)(16)(17)(18)(19)(20). On the other hand, some more general methods (4-11, 14, 21, 22), which may find broader application have also been pre-FIG. 1. Pulse sequences for measurement of long-range heteronuclear sented. coupling constants. Thin and thick bars represent 90Њ and 180Њ pulses,

An ideal method for measurement of long-range heterorespectively. Dashed pulses and X decoupling were applied only in some