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Sensitivity- and Gradient-Enhanced Heteronuclear Coupled/Decoupled HSQC–TOCSY Experiments for Measuring Long-Range Heteronuclear Coupling Constants

✍ Scribed by Katalin E. Kövér; Victor J. Hruby; Dušan Uhrı́n

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
122 KB
Volume
129
Category
Article
ISSN
1090-7807

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✦ Synopsis

A pulsed field gradient version of the sensitivity-enhanced 2D HSQC-TOCSY experiment is proposed for measurement of long-range heteronuclear coupling constants. The coupling constants are obtained by computer-aided analysis of mixed-phase multiplets with and without the heteronuclear splitting. Generation of pure phase data is not required. Since large 1JXH and JHH couplings are used for coherence transfer, small nJXH can be measured accurately, which could be difficult to obtain from purely heteronuclear polarization transfer experiments.

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