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Selective J-resolved HMBC, an efficient method for measuring heteronuclear long-range coupling constants

✍ Scribed by Kazuo Furihata; Mitsuru Tashiro; Haruo Seto

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
274 KB
Volume
47
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

An efficient pulse sequence for measuring long‐range CH coupling constants (J~CH~) named selective J‐resolved HMBC has been developed by replacing a ^1^H 180° pulse with a selective ^1^H 180° pulse and the HMBC pulse scheme with the constant time (CT) HMBC employed in the J‐resolved HMBC pulse sequence that we reported previously. The novel pulse sequence providing only long‐range J~CH~ cross peaks for easy and accurate analysis enables to overcome disadvantages of the previous HMBC‐based pulse sequences (J‐resolved HMBC‐1) along with maintaining high sensitivity. The efficiency of measuring long‐range J~CH~ using the proposed pulse sequence has been demonstrated in applications to the complicated natural products, portmicin and monazomycin. Copyright © 2009 John Wiley & Sons, Ltd.

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