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Direct Catalytic Asymmetric Mannich Reactions of Malonates and β-Keto Esters.

✍ Scribed by Mauro Marigo; Anne Kjaersgaard; Karsten Juhl; Nicholas Gathergood; Karl Anker Joergensen

Publisher
John Wiley and Sons
Year
2003
Weight
219 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)

Direct Catalytic Asymmetric Mannich-Type
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## Abstract **Weich hilft hart**: Die Titelreaktion zwischen Thioamiden und __N__‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereakti