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Direct Catalytic Asymmetric Mannich Reactions of Malonates and β-Keto Esters

✍ Scribed by Mauro Marigo; Anne Kjærsgaard; Karsten Juhl; Nicholas Gathergood; Karl Anker Jørgensen

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
193 KB
Volume
9
Category
Article
ISSN
0947-6539

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## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)

Direct Catalytic Asymmetric Mannich-Type
Direct Catalytic Asymmetric Mannich-Type Reaction of Thioamides
✍ Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 402 KB

## Abstract **Weich hilft hart**: Die Titelreaktion zwischen Thioamiden und __N__‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereakti