Direct Catalytic Asymmetric Aldol-Tishchenko Reaction
โ Scribed by Masakatsu Shibasaki; Takashi Ohshima
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
## Abstract The development of a direct catalytic asymmetric aldolโTishchenko reaction and the nature of its catalyst are described. An aldolโTishchenko reaction of various propiophenone derivatives with aromatic aldehydes was promoted by [LaLi~3~(binol)~3~] (LLB), and reactivity and enantioselecti
In the synthesis of complex molecular targets, the ability to control the stereoselectivity of the aldol reaction has raised this process to a level of prominence shared by few reactions. In most cases, however, the stoichiometric transformation of the active methylene partner into its enolate or an