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Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer

✍ Scribed by Maria Nowacka-Zawisza; Magdalena Brys; Hanna Romanowicz-Makowska; Andrzej Kulig; Wanda M. Krajewska

Book ID: 115175915
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 70 KB
Volume: 58
Category: Article
ISSN: 1320-5463
DOI: 10.1111/j.1440-1827.2008.02223.x

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## Abstract Marked variation in phenotypic expression among __BRCA1__ and __BRCA2__ mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C‐terminus of the AIB1 protein (amplified