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A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers

✍ Scribed by Kadouri, L; Kote-Jarai, Z; Hubert, A; Durocher, F; Abeliovich, D; Glaser, B; Hamburger, T; Eeles, R A; Peretz, T


Book ID
109998072
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
85 KB
Volume
90
Category
Article
ISSN
0007-0920

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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in