Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations
✍ Scribed by Gonzalez, R; Silva, J M; Dominguez, G; Garcia, J M; Martinez, G; Vargas, J; Provencio, M; España, P; Bonilla, F
- Book ID
- 110002503
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 100 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Previous studies have shown that breast cancers have more aggressive pathologic features in young women. In order to examine genetic alterations associated with early‐onset breast cancer, 31 patients with no known family history, aged 26–35 years at diagnosis, were examined for loss of
BACKGROUND. BRCA1 and BRCA2 participate in cell cycle progression, apoptosis, and DNA repair pathways. The latter role may be mediated by interaction with DNA recombinase Rad51. The purpose of this study was to evaluate the effects of genotoxic and other cytotoxic agents on expression of DNA damage-