Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics
β Scribed by F. Worek; C. Diepold; P. Eyer
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 205 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Methamidophos (O, Sβdimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied __in vitro.__ The pseudoβbiomolecular rate constant of inhibition was 3.14 Β± 0.22 Γ 10^3^ M^β1^ min^β1^ for erythrocyte cholinesterase and 1.85 Β± 0.01 Γ 10^3^ M^β1^ m
The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant