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Inhibition of human erythrocyte and plasma cholinesterases by methamidophos

✍ Scribed by Casey P. Robinson; Donald Beiergrohslein

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
150 KB
Volume
2
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

Methamidophos (O, S‐dimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied in vitro. The pseudo‐biomolecular rate constant of inhibition was 3.14 Β± 0.22 Γ— 10^3^ M^βˆ’1^ min^βˆ’1^ for erythrocyte cholinesterase and 1.85 Β± 0.01 Γ— 10^3^ M^βˆ’1^ min^βˆ’1^ for plasma cholinesterase. Thus methamidophos, although quite toxic to mammals, is a slow, rather non‐selective inhibitor of human cholinesterases, as was also observed previously in rats.

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